Faculty Research 1980 - 1989

Title

Inherited primary hypothyroidism in mice.

Document Type

Article

Publication Date

1981

Keywords

Animal, Cholesterol, Chromosome-Mapping, Crosses-Genetic, Female, Genes-Recessive, Human, Hypothyroidism: bl, fg, ve, Male, Mice, Mice-Mutant-Strains: ge, Rodent-Diseases: fg, SUPPORT-U-S-GOVT-P-H-S, Thyroid-Gland: pa, Thyrotropin: me

JAX Location

44,408

JAX Source

Science. 1981 Apr 3; 212(4490):61-3.

Grant

AM17947, RR01138, NS09378

Abstract

A new autosomal recessive mutation that causes hypothyroidism has been identified in mice. The gene, herein named hypothyroid (hyt), has been mapped on chromosome 12 approximately 30 units from the centromere. The mutants are characterized by retarded growth, infertility, mild anemia, elevated serum cholesterol, very low to undetectable serum thyroxine, and elevated serum thyroid-stimulating hormone. Thyroid glands are in the normal location but are reduced in size and hypoplastic. Mutant mice respond to thyroid hormone therapy by improved growth and fertility. These findings suggest that the hyt mutant gene results in primary hypothyroidism unresponsive to thyroid-stimulating hormone.

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