Faculty Research 1980 - 1989

Title

Stumbler, a new mutant mouse with cerebellar disease.

Document Type

Article

Publication Date

1981

Keywords

Cerebellum: ah, hi, Crosses-Genetic, Dendrites: ul, Mice, Mice-Inbred-C3H, Mice-Inbred-C57BL, Mice-Neurologic-Mutants, Microscopy-Electron, Motor-Skills: ph, Mutation, Purkinje-Cells: ul, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

JAX Location

45,283

JAX Source

Brain-Res. 1981 Mar 9; 208(1):251-5.

Grant

NS11234, NS09378, RR01183, +

Abstract

A new mutant mouse named Stumbler (stu) displays clinical features suggesting a cerebellar lesion. The main light microscopic findings, based on a Golgi technique and on sections of plastic embedded material, are that Purkinje cells in the mutant cerebellum have small dendritic arborizations and exhibit immature spines on their somata. Purkinje cells also contain an increased number of mitochondrial profiles both in cell bodies and in swellings on dendrites.

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