Faculty Research 1980 - 1989

Title

A murine stage-specific embryonic antigen (SSEA-2) is expressed on some murine SV40-transformed cells.

Document Type

Article

Publication Date

1981

Keywords

Animal, Blastocyst: im, Cell-Line, Cell-Transformation-Viral, Embryo: im, Female, Immune-Sera, Mice, Mice-Inbred-BALB-C, Precipitation, Rabbits, SUPPORT-U-S-GOVT-NON-P-H-S, SUPPORT-U-S-GOVT-P-H-S, SV40-Virus: im, Teratoma: im

JAX Source

J Immunol 1981 Aug; 127(2):632-6.

Grant

CA18470, HD12487, CA25875

Abstract

A stage-specific embryonic antigen-2 (SSEA-2) found on murine preimplantation embryos is maximally expressed on 4- to 8-cell stage embryos and is present in decreasing amounts of morulae and blastocysts. This antigenic determinant is also expressed on murine teratocarcinoma cells, sperm, and some, but not all, SV40-transformed mouse cell lines. Analysis of solubilized immunoprecipitates by SDS-gel electrophoresis indicates that this cell surface molecule is not the 54,000 m.w. protein shared by teratocarcinoma and SV40-transformed cell lines.

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