Faculty Research 1980 - 1989

Title

Upg-2: a urinary pepsinogen variant located on chromosome 1 of the mouse.

Document Type

Article

Publication Date

1982

Keywords

Animal, Chromosome-Mapping, Electrophoresis-Polyacrylamide-Gel, Linkage-(Genetics), Mice, Mice-Inbred-Strains: ge, ur, Pepsinogen, SUPPORT-U-S-GOVT-P-H-S, Variation-(Genetics)

JAX Source

Biochem-Genet. 1982 Dec; 20(11-12):1211-9.

Grant

GM18684

Abstract

Acrylamide gel electrophoresis of mouse urine distinguishes two groups of pepsinogens, the fast-migrating group A and the slow-migrating group B. Inbred mouse strains fall into two categories with respect to group B pepsinogens, one expressing a single-banded and the other a double-banded phenotype. This variation is controlled by a single locus, urinary pepsinogen-2 or Upg-2, which has at least two alleles, Upg-2s and Upg-2d. Typing of recombinant inbred strains suggests that the location of the Upg-2 locus is on chromosome 1, in the vicinity of loci coding for other peptidases, namely, Pep-2 and Rnr, and of the Acf-1 locus.

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