Faculty Research 1980 - 1989

Title

Physiological and behavioral correlates of lifespan in aged C57BL/6J mice.

Document Type

Article

Publication Date

1982

Keywords

Animal, Avoidance-Learning: ph, Behavior-Animal: ph, Collagen: me, Exploratory-Behavior, Hematocrit, Hemoglobins: an, Longevity, Male, Mice, Mice-Inbred-C57BL: ph, Protein-Denaturation, Regression-Analysis, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Exp-Gerontol. 1982; 17(4):295-303.

Grant

AG00250, AG01755, AG00594, +

Abstract

Physiological and behavioral measurements were made in a cohort of 29-month-old male C57BL/6J mice to determine whether any correlated significantly with lifespan. Significant linear relationships with lifespan were found among the physiological measures, including hematocrit and hemoglobin levels and collagen denaturation rate; however, body weight failed to be a significant predictor of survival. Among the behavioral variables studied, significant quadratic relationships with lifespan were found for exploratory activity and passive avoidance learning, while performance on a rotorod and a tightwire showed no significant relationships with lifespan. Through the use of multiple regression techniques, about one-third of the variance in lifespan could be explained by a combination of physiological variables, and about two-fifths could be explained by a combination of behavioral variables.

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