Faculty Research 1980 - 1989
Molecular cloning of a family of retroviral sequences found in chimpanzee but not human DNA.
Document Type
Article
Publication Date
1982
Keywords
C-Type-Viruses: ge, Chimpansee-troglodytes: ge, mi, Cloning-Molecular, DNA: ge, DNA-Viral: ge, Escherichia-Coli: ge, Human, Phage-Lambda: ge, Plasmids, Repetitive-Sequences-Nucleic-Acid, Species-Specificity
First Page
914
Last Page
924
JAX Source
J-Virol. 1982 Sep; 43(3):914-24.
Abstract
A number of retrovirus-like sequences have been cloned from chimpanzee DNA which constitute the chimpanzee homologs of the endogenous colobus type C virus CPC-1. One of the clones contains a nearly complete viral genome, but others have sustained deletions of 1 to 2 kilobases in the polymerase gene. The pattern of related sequences detected in other primate species is consistent with the genetic transmission of these sequences for millions of years. However, the appropriately related sequences have not been detected in human, gibbon, or orangutan DNAs. These results suggest either that this family of sequences has been deleted from humans, gibbons, and orangutans, or that the genes were recently acquired in the chimpanzee and gorilla lineages.
Recommended Citation
Bonner TI,
Birkenmeier EH,
Gonda MA,
Mark GE,
Searfoss GH,
Todaro GJ.
Molecular cloning of a family of retroviral sequences found in chimpanzee but not human DNA. J-Virol. 1982 Sep; 43(3):914-24.