Faculty Research 1980 - 1989


Immunodominance in the immune response to "multiple" histocompatibility antigens.

Document Type


Publication Date



Comparative-Study, Cytotoxicity-Immunologic, H-2-Antigens: ge, Histocompatibility-Antigens: im, Immunization, In-Vitro, Killer-Cells: im, Major-Histocompatibility-Complex, Mice, SUPPORT-U-S-GOVT-P-H-S, T-Lymphocytes: im

JAX Source

Immunogenetics. 1982; 16(1):47-58.


AI16052, AI13130, CA10815


Cytotoxic effector T cells putatively specific for multiple non-H-2 histocompatibility (H) antigens were generated by immunizing and boosting C57BL/6 and B6.C-H-2d mice with BALB.B and BALB/c stimulator cells, respectively. The generated effectors were tested for cell-mediated lympholysis on a panel of targets whose BALB/c-derived non-H-2 H antigens were donated by CXB recombinant inbred mice. The spectrum of reactivity of cytotoxic effector T cells with CXB targets demonstrated that the effectors did not recognize multiple H antigens but rather preferentially recognized a single immunodominant non-H 2 antigen. The identity of the immunodominant H antigen was determined by the H-2 genotype of the stimulator cells when (B6 x B6.C-H-2d)F1 cytotoxic effectors were tested. These observations indicate that despite the fact that responders were challenged with more than 40 individual non-H-2 H antigens, they preferentially responded to single immunodominant antigen.

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