Faculty Research 1980 - 1989

Title

Dissociation of two signals required for activation of resting B cells.

Document Type

Article

Publication Date

1982

Keywords

Antibody-Formation, B-Lymphocytes: im, H-2-Antigens, Immunoglobulins-Surface: im, Lymphocyte-Cooperation, Lymphocyte-Transformation, Mice, Receptors-Antigen-B-Cell: im, SUPPORT-NON-U-S-GOVT, T-Lymphocytes: im

JAX Source

Proc-Natl-Acad-Sci-USA. 1982 Mar; 79(6):1989-93.

Abstract

Cellular interactions involved in the T cell-dependent activation of B cells were analyzed by using lines and clones of helper T cells specific for determinants expressed on the B cell surface. Activation of male antigen-, M locus-, and H-2-specific T cells was shown to support polyclonal Ig production by a population of B cells that did not require T-cell-B-cell interaction for induction/amplification. However, these T cells alone did not activate gradient-purified small (resting) B cells. The activation of small B cells was shown to require not only a signal derived through an antigen-specific T-helper cell-B cell interaction but in addition a second signal that could be provided by anti-Ig antibodies.

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