Faculty Research 1980 - 1989

Title

Analysis of growth hormone genes in mice with genetic defects of growth hormone expression.

Document Type

Article

Publication Date

1982

Keywords

Animal, Comparative-Study, Disease-Models-Animal, DNA: ge, Genes-Structural, Homozygote, Human, Hypopituitarism: fg, Leukocytes: an, Mice, Mice-Mutant-Strains: ge, Mutation, Somatotropin: ge, df, Species-Specificity, SUPPORT-U-S-GOVT-P-H-S

JAX Source

J-Endocrinol. 1982 Mar; 92(3):405-7.

Grant

AM00423, AM28246, AM17947

Abstract

Restriction endonuclease analysis of genomic DNA was carried out for three types of dwarf mice (Little, Ames dwarf and Snell dwarf) that have genetic defects in GH expression. We found the GH genes to be present in homozygotes for each mutant allele as well as in their control litter-mates. These three type of dwarf mice may be useful in studying the molecular basis of inherited GH deficiency and as models for analogous genetic disorders of human GH expression.

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