Faculty Research 1980 - 1989

Title

Expression on normal lymphocytes of two cell surface antigens, XenCSA and GIX, related to the major glycoproteins (gp70) of murine leukemia viruses.

Document Type

Article

Publication Date

1982

Keywords

Antigens-Surface: ge, im, Chromosome-Mapping, Crosses-Genetic, Female, Lymphocytes: im, Male, Mice, Mice-Inbred-C3H, Mice-Inbred-C57BL, Mice-Inbred-DBA, Mice-Inbred-Strains, Mouse-Leukemia-Viruses: ge, im, Phenotype, Recombination-Genetic, SUPPORT-U-S-GOVT-P-H-S, Viral-Proteins: ge, im

JAX Source

J-Immunol. 1982 May; 128(5):2111-5.

Grant

N01-CP-8-1054, N01-CP-33255

Abstract

XenCSA and GIX are two cell surface antigens related to the major envelope glycoproteins (gp70) of murine leukemia viruses. The levels of expression of these gp70 determinants were assessed in 36 recombinant inbred mouse strains and selected backcrosses derived from crosses between C57BL/6 with DBA/2 and C3H/He. These two antigens segregated in backcross mice and showed a different strain distribution pattern among the recombinant inbred mice, demonstrating that XenCSA and GIX are distinct genetic markers for different endogenous gp70 sequences. It was also shown that independent sets of gene regulate the expression of XenCSA and GIX.

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