Faculty Research 1980 - 1989

Title

Evidence for independent regulation of dolichol and cholesterol synthesis in developing mouse brain.

Document Type

Article

Publication Date

1980

Keywords

Animals-Newborn: me, Brain: me, Cholesterol: bi, Diterpenes: bi, Dolichol: bi, In-Vitro, Mice, Mice-Inbred-DBA: me, SUPPORT-U-S-GOVT-P-H-S, Time-Factors

JAX Source

Biochim-Biophys-Acta. 1980 Aug 11; 619(2):432-5.

Grant

CA02758

Abstract

In order to investigate the regulatory inter-relationships between the branching pathways of dolichol and cholesterol synthesis, we have measured the changing rates of synthesis for these two lipids in developing mouse brains. A sharp peak in the rate of dolichol synthesis occured at 3-7 days after birth which did not coincide with changes in cholesterol synthesis, suggesting independent regulation of dolichol and cholesterol synthesis in developing mouse brains.

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