Faculty Research 1980 - 1989
Biosynthesis and processing of a human precursor complement protein, pro-C3, in a hepatoma-derived cell line.
Document Type
Article
Publication Date
1982
Keywords
Cell-Line, Complement-3: bi, Human, Liver-Neoplasms-Experimental: me, Macromolecular-Systems, Molecular-Weight, Protein-Precursors: me, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S
First Page
399
Last Page
400
JAX Source
Science 1982 Jan 22;215(4531):399-400
Grant
AM16392, CA18470, CA25875
Abstract
A 180,000-dalton single-chain molecule (human pro-C3) is the precursor of the third component of human complement (C3), a disulfide-linked two-chain protein. The pro-C3 is converted by limited proteolysis to C3. The relationship between pro-C3 and C3 was established with the use of Hep G2, a cell line derived from a human hepatocellular carcinoma, which synthesizes at least 17 plasma proteins.
Recommended Citation
Morris KM,
Goldberger G,
Colten HR,
Aden DP,
Knowles BB.
Biosynthesis and processing of a human precursor complement protein, pro-C3, in a hepatoma-derived cell line. Science 1982 Jan 22;215(4531):399-400