Faculty Research 1980 - 1989

Title

Biosynthesis and processing of a human precursor complement protein, pro-C3, in a hepatoma-derived cell line.

Document Type

Article

Publication Date

1982

Keywords

Cell-Line, Complement-3: bi, Human, Liver-Neoplasms-Experimental: me, Macromolecular-Systems, Molecular-Weight, Protein-Precursors: me, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Science 1982 Jan 22;215(4531):399-400

Grant

AM16392, CA18470, CA25875

Abstract

A 180,000-dalton single-chain molecule (human pro-C3) is the precursor of the third component of human complement (C3), a disulfide-linked two-chain protein. The pro-C3 is converted by limited proteolysis to C3. The relationship between pro-C3 and C3 was established with the use of Hep G2, a cell line derived from a human hepatocellular carcinoma, which synthesizes at least 17 plasma proteins.

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