Biosynthesis and processing of a human precursor complement protein, pro-C3, in a hepatoma-derived cell line.
Cell-Line, Complement-3: bi, Human, Liver-Neoplasms-Experimental: me, Macromolecular-Systems, Molecular-Weight, Protein-Precursors: me, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S
Science 1982 Jan 22;215(4531):399-400
AM16392, CA18470, CA25875
A 180,000-dalton single-chain molecule (human pro-C3) is the precursor of the third component of human complement (C3), a disulfide-linked two-chain protein. The pro-C3 is converted by limited proteolysis to C3. The relationship between pro-C3 and C3 was established with the use of Hep G2, a cell line derived from a human hepatocellular carcinoma, which synthesizes at least 17 plasma proteins.
Morris, K M.; Goldberger, G; Colten, H R.; Aden, D P.; and Knowles, B B., " Biosynthesis and processing of a human precursor complement protein, pro-C3, in a hepatoma-derived cell line." (1982). Faculty Research 1980 - 1989. 381.