Faculty Research 1980 - 1989


H-2Kb mutations limit the CTL response to SV40 TASA.

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Publication Date



Antigenic-Determinants, Antigens-Neoplasm: ge, im, Antigens-Viral: ge, im, Cross-Reactions, Cytotoxicity-Immunologic, H-2-Antigens: ge, im, Mice, Mice-Inbred-C57BL, Mutation, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, SV40-Virus: ge, im

JAX Source

J Immunol 1982 Jan;128(1):243-6


CA18470, CA10815, AI16052


The cytotoxic T lymphocyte (CTL) responses directe towards SV40 tumor-associated specific antigen (TASA) in nine strains of spontaneously arising Kb mutant mice were analyzed. All nine mutants generated normal levels of H-2Db-restricted response, but the K-end-restricted CTL response varied. B6.C-H-2bm1 (bm1) did not produce K-end-restricted SV40 TASA-specific CTL upon immunization, and SV40-transformed bm1 cells were not lysed by intra-H-2 recombinant Kb [B10.A(5R)] CTL. Nonreciprocal cross-reactive lysis was seen between B6-H-2bm8 (bm8) and B10.A(5R). Strain B6-H-2bm8 mice produce highly specific Kbm8-restricted CTL that lyse SV40-transformed bm8 cells (Kbm8SV) but not B10.A(5R) target cells (K5RSV), although Kbm8SV targets can be partially lysed by B10.A(5R) CTL. The other seven Kb mutants cross-react with B10.A(5R). These experiments definitively show that genes mapping to the K and/or D region directly control the H-2-restricted CTL response to SV40 TASA.

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