Faculty Research 1980 - 1989


Decline in male mouse pheromone with age.

Document Type


Publication Date



Animal, Female, Male, Mice, Mice-Inbred-BALB-C: ph, Pheromones, Reproduction, Species-Specificity, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Biol-Reprod. 1983 Aug; 29(1):81-6.


AG01755, AG00594


An age-related decline in urinary-borne pheromone was found in male C57BL/6J mice aged from 2 to 30 months. Pheromone activity, estimated by bioassay, declined sharply after about 10 months of age. Two other strains of mice tested (DBA/2J and CBA/HT6J) also appeared to show an age-related decline in pheromone activity. Within each strain, however, pheromone activity was consistently similar to or higher than that of the C57BL/6J male mice. The DBA/2J and BALB/cWt strains appeared to be high pheromone producers, and the C57BL/6J and CBA/HT6J strains, low producers. This report is the first demonstration of a decline with age in male mouse pheromone activity. This decline appears to be synchronized with the well-defined loss of reproductive function in female mice.