Faculty Research 1980 - 1989

Title

H-2-linked gene(s) influence the granulomatous reaction to viable Mycobacterium lepraemurium in the mouse.

Document Type

Article

Publication Date

1983

Keywords

Crosses-Genetic, Granuloma: et, fg, im, H-2-Antigens: ge, Linkage-(Genetics), Mice, Mice-Inbred-C3H, Mice-Inbred-C57BL, Mycobacterium-Infections: fg, co, Mycobacterium-Lepraemurium: im, Species-Specificity, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

JAX Location

46,158

JAX Source

Scand-J-Immunol. 1983 Jul; 18(1):59-63.

Grant

GM18684

Abstract

The genetic control of the granulomatous response to viable Mycobacterium lepraemurium (MLM) was studied in C3H and C57BL/6 inbred strains, BXH recombinant inbred strains, (C3H X C57BL) F1 hybrids, and backcross mice. The results indicate that an autosomal dominant gene, or linked complex of genes, has a marked influence on the footpad reaction to viable MLM. The distribution of responders and non-responders among 12 BXH recombinant inbred strains and linkage analysis in C3H X (C3H X C57BL)F1 backcross mice indicated that the response gene(s) are linked to the H-2 complex on chromosome 17. The same gene(s) also influence host restriction of MLM multiplication and thus appear to be the first H-2-linked gene(s) influencing resistance to a bacterial infection.

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