Faculty Research 1980 - 1989


Rabbit linkage group VIII: the alleles of the prt gene.

Document Type


Publication Date



Animal, Electrophoresis-Polyacrylamide-Gel, Female, Genes-Structural, Immunoglobulins-Kappa-Chain: ge, Immunoglobulins-Light-Chain: ge, Linkage-(Genetics), Male, Phenotype, Rabbits: ge, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Biochem-Genet. 1983 Jun; 21(5-6):511-26.


GM27096, RR00251


The prt gene which is linked to the rabbit immunoglobulin kappa-light chain gene, ab, has two phenotypes, PRT+ and PRT-. These phenotypes can be distinguished only when serum proteins from different rabbits are separated by polyacrylamide gel electrophoresis. The serum protein profiles for PRT+ rabbits show a band that is horetic variants of PRT which are located in areas of the polyacrylamide gel obscured by other serum proteins. These results and other suggest that the prt gene has three alleles, the prta allele encoding the protein found in PRT+ rabbits and the prtb and prtc alleles encoding the two electrophoretic variants found in PRT- rabbits.

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