Faculty Research 1980 - 1989

Title

Spontaneous tumors of the prostate gland in inbred strains of mice.

Document Type

Article

Publication Date

1983

Keywords

Aging, Animal, Comparative-Study, Male, Mice, Mice-Inbred-C57BL, Mice-Inbred-Strains, Neoplasms-Experimental: pa, Prostate: gd, Prostatic-Neoplasms: pa, Species-Specificity, SUPPORT-U-S-GOVT-P-H-S

JAX Source

JNCI. 1983 Jan; 70(1):199-208.

Grant

CA20226

Abstract

Spontaneous tumors of the prostate gland in the house mouse (Mus musculus) have rarely been described. In a histologic survey of prostate glands from old (greater than 700 days of age) mice, we have observed 2 primary adenocarcinomas of the prostate gland, 1 in a 1,047-day-old C57BL/6J mouse (DEH 1009) and 1 with metastases to the kidney and lungs in a 778-day-old C57BL/KsJ mouse (DEH 705C). We have also found a rhabdomyosarcoma of the prostate gland in a C57BL/6J mouse (DEH 1121C) 732 days old. The histologic characteristics of these tumors, and of the prostate glands of mice of similar ages without prostatic neoplastic involvement, including a 736-day-old CBA/CaJ mouse (DEH 849) with adenomatous hyperplasia, are described.

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