Faculty Research 1980 - 1989
Immunohistochemical localization of the mouse stage-specific embryonic antigen 1 in human tissues and tumors.
Document Type
Article
Publication Date
1983
Keywords
Cell-Line, Female, Glycolipids: an, Human, Immunoenzyme-Techniques, Male, Neoplasms: im, pa, SUPPORT-U-S-GOVT-NON-P-H-S, SUPPORT-U-S-GOVT-P-H-S, Tissue-Distribution
First Page
669
Last Page
678
JAX Source
Cancer Res 1983 Feb;43(2):669-78
Grant
CA23097, GM29040, CA18470
Abstract
Normal human tissues and various human tumors were surveyed by immunohistochemical techniques for expression of the stage-specific embryonic antigen 1 (SSEA-1). The antibody reacted with many normal and neoplastic human tissues. In most instances, equivalent human and mouse tissues expressed SSEA-1; however, different tissue localization patterns were sometimes seen between these two species. Most SSEA-1-positive tumors originate from tissues that normally expressed this antigen; however, some breast and ovarian tumors are SSEA-1 positive, and these organs are SSEA-1 negative. SSEA-1-positive tumors were composed of both immunoreactive and nonreactive tumor cells. These data show that SSEA-1, initially defined as a mouse embryonic antigen, represents a heterogenetic antigen present in many normal human tissues. It is retained on many but not all neoplastic cells originating in these normal tissues and also appears on the surface of some tumor cells developing in SSEA-1-negative tissues.
Recommended Citation
Fox N,
Damjanov I,
Knowles BB,
Solter D.
Immunohistochemical localization of the mouse stage-specific embryonic antigen 1 in human tissues and tumors. Cancer Res 1983 Feb;43(2):669-78