Faculty Research 1980 - 1989

Title

Monoclonal antibody to SV40 T-antigen blocks lysis of cloned cytotoxic T-cell line specific for SV40 TASA.

Document Type

Article

Publication Date

1983

Keywords

Antibodies-Monoclonal, Antibodies-Viral, Antigenic-Determinants, Antigens-Neoplasm: im, Antigens-Viral: im, Cell-Line, Cell-Transformation-Viral, Cytotoxicity-Immunologic, Histocompatibility-Antigens: im, Mice, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, SV40-Virus: im, ph, T-Lymphocytes-Cytotoxic: im

JAX Source

Virology 1983 Feb;125(1):1-7

Grant

CA18470, CA10815

Abstract

The lysis of SV40-transformed target cells by a cloned cytotoxic T cell line (CTB6) that is SV40 TASA-specific and H-2Kb-restricted is blocked by a monoclonal antibody reactive with the SV40 T-antigen. The blocking is maximized at high antibody concentrations and low effector-to-target cell ratios. These data indicate that at least one antigenic determinant of the SV40 T-antigen molecule is expressed at the cell surface and is either recognized by this cytotoxic T lymphocyte or is proximate to that determinant recognized by this cytotoxic T lymphocyte.

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