Faculty Research 1980 - 1989

Title

Amyloidosis development in LLC mice.

Document Type

Article

Publication Date

1984

Keywords

Amyloidosis: pa, Animal, Gold, Mice, Mice-Inbred-Strains, Microscopy-Electron, Spleen: ul, SUPPORT-U-S-GOVT-P-H-S

JAX Location

89

JAX Source

Exp-Cell-Biol. 1984; 52(6):339-46.

Grant

AG02122

Abstract

Using electron microscopy and the protein A-gold labelling technique we studied amyloidosis in the LLC mice, an inbred strain developing amyloidosis spontaneously. We found that the reticular cells lining around the sinuses in the red pulp of the spleen were converted to amyloid. Evidence suggests that the amyloid originates in the cells themselves. The process of amyloid formation is discussed.

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