Inhibition of sterol biosynthesis by 14 alpha-hydroxy-delta 7-sterols.

Authors

G J. Schroepfer
R A. Pascal
A A. Kandutsch

Document Type

Article

Publication Date

1980

Keywords

Cholestenes, Cholestenones, Hydroxymethylglutaryl-CoA-Reductases: ai, L-Cells: de, me, Mice, Sterols: bi, SUPPORT-U-S-GOVT-P-H-S

First Page

518

Last Page

518

JAX Source

Experientia. 1980 May 15; 36(5):518.

Abstract

5 alpha-Cholest-7-en-3 beta, 14 alpha-diol and 5 alpha-cholest-7-en-14 alpha-ol-3-one have been found to be potent inhibitors of the synthesis of digitonin-precipitable sterols in L cells in culture and to reduce the levels of HMG-CoA reductase activity in these cells.

Recommended Citation

Schroepfer GJ, Pascal RA, Kandutsch AA. Inhibition of sterol biosynthesis by 14 alpha-hydroxy-delta 7-sterols. Experientia. 1980 May 15; 36(5):518.