Inhibition of sterol biosynthesis by 14 alpha-hydroxy-delta 7-sterols.
Cholestenes, Cholestenones, Hydroxymethylglutaryl-CoA-Reductases: ai, L-Cells: de, me, Mice, Sterols: bi, SUPPORT-U-S-GOVT-P-H-S
Experientia. 1980 May 15; 36(5):518.
5 alpha-Cholest-7-en-3 beta, 14 alpha-diol and 5 alpha-cholest-7-en-14 alpha-ol-3-one have been found to be potent inhibitors of the synthesis of digitonin-precipitable sterols in L cells in culture and to reduce the levels of HMG-CoA reductase activity in these cells.
Schroepfer, G J.; Pascal, R A.; and Kandutsch, A A., " Inhibition of sterol biosynthesis by 14 alpha-hydroxy-delta 7-sterols." (1980). Faculty Research 1980 - 1989. 52.