Faculty Research 1980 - 1989

Title

Inhibition of sterol biosynthesis by 14 alpha-hydroxy-delta 7-sterols.

Document Type

Article

Publication Date

1980

Keywords

Cholestenes, Cholestenones, Hydroxymethylglutaryl-CoA-Reductases: ai, L-Cells: de, me, Mice, Sterols: bi, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Experientia. 1980 May 15; 36(5):518.

Abstract

5 alpha-Cholest-7-en-3 beta, 14 alpha-diol and 5 alpha-cholest-7-en-14 alpha-ol-3-one have been found to be potent inhibitors of the synthesis of digitonin-precipitable sterols in L cells in culture and to reduce the levels of HMG-CoA reductase activity in these cells.

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