Faculty Research 1980 - 1989

Title

Structural asymmetries in brains of mice selected for strong lateralization.

Document Type

Article

Publication Date

1984

Keywords

Brain: ah, hi, Cerebral-Cortex: ah, hi, Comparative-Study, Corpus-Striatum: ah, hi, Female, Hippocampus: ah, hi, Laterality: ph, Limbic-System: ah, hi, Mice, Mice-Inbred-BALB-C, Mice-Inbred-C57BL, Mice-Inbred-DBA, Mice-Inbred-Strains, Species-Specificity, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-NON-P-H-S, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Brain-Res. 1984 Sep 24; 310(2):393-6.

Grant

GM23618

Abstract

The brains of 18 female mice from two lines selectively bred for lateralization of paw preference were investigated for morphological asymmetries in 5 horizontal sections from mid-dorsoventral planes. Cortical thickness was measured at orbitofrontal, somatosensory and lateral entorhinal regions; volume measures included the hippocampal formation and the striatum. Mice of the strongly lateralized line had stronger asymmetries in 4 of the 5 variables. Discriminant analysis showed that the two mouse lines could be differentiated best by their asymmetries in orbitofrontal cortex and hippocampus (P less than 0.02).

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