Faculty Research 1980 - 1989

Title

Adrenal changes in genetically hypothyroid mice.

Document Type

Article

Publication Date

1984

Keywords

Animal, Female, Hypothyroidism: pp, pa, Mice, Mice-Mutant-Strains, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, Thyroid-Gland-Desiccated

JAX Source

J-Endocrinol. 1984 Sep; 102(3):277-80.

Grant

AM17947

Abstract

The adrenocortical X-zone was very poorly developed in young female mice homozygous for the hypothyroid, hyt, mutation, Feeding the mice thyroid powder resulted in the development of an X-zone. This subsequently degenerated in the same way as the X-zone found in the normal litter-mates of the mutants. We suggest that the adrenocortical effects may be due to changes in prolactin stimulation consequent upon the lack of response to thyrotrophin of the mutants.

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