Faculty Research 1980 - 1989

Title

Evaluations of wasted mouse fibroblasts and SV-40 transformed human fibroblasts as models of ataxia telangiectasia in vitro.

Document Type

Article

Publication Date

1984

Keywords

Ataxia-Telangiectasia: pa, Bleomycins, Cell-Line, Cell-Survival, Cell-Transformation-Viral, Disease-Models-Animal, DNA-Replication: de, re, Gamma-Rays, Human, Mice, Mice-Mutant-Strains: ph, SUPPORT-U-S-GOVT-P-H-S, SV40-Virus

JAX Source

Mutat-Res. 1984 Aug; 140(4):219-22.

Grant

GM21313, GM30180, AI08998

Abstract

Fibroblast cultures from wasted mice have been derived and the responses of these cultures to bleomycin treatment or gamma-irradiation have been examined. No differences were observed between wasted fibroblasts and littermate controls in the post-treatment inhibition of DNA replication. In contrast, a human SV-40 transformed ataxia telangiectasia fibroblast line mimicked the abnormal response of primary ataxia telangiectasia fibroblasts to gamma-rays or bleomycin and thus appears to be a useful in vitro model of ataxia telangiectasia.

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