Faculty Research 1980 - 1989

Title

Histocompatibility-2 system in wild mice. X. Frequencies of H-2 and Ia antigens in wild mice from Europe and Africa.

Document Type

Article

Publication Date

1980

Keywords

Animal, Antigenic-Determinants, Egypt, Europe, Gene-Frequency, H-2-Antigens, Histocompatibility-Antigens, Mice, Phenotype, SUPPORT-U-S-GOVT-P-H-S

JAX Source

J-Immunol. 1980 Jun; 124(6):2675-81.

Abstract

In this study, data are presented on serologic H-2 typing of 320 wild mice collected in several parts of Europe and Egypt. The sample was typed for 39 class I (K, D) and 16 class II (Ia) antigens. The phenotype frequencies of class I and class II antigens showed high variability in their distribution among different areas, ranging from absence or presence in low frequency in one area to presence in about one-half of the mice in another area. The average phenotypic frequency of class I private antigens was 6.3%; at least 60% of class I alleles (blanks) could not be identified with the available reagents. The data suggest that there might be more than 100 alleles for each class I locus, H-2K and H-2D. The average phenotypic frequencies of Ia-1 private antigens was 10.8%. About 75% of Ia-1 alleles (blanks) could not be identified. The number of Ia-1 alleles was estimated to be in the range of 20 to 50.