Faculty Research 1980 - 1989

Title

Adaptive immune defects and delayed rejection of allogeneic tumor cells in beige mice.

Document Type

Article

Publication Date

1984

Keywords

Antibody-Dependent-Cell-Cytotoxicity, Cytotoxicity-Immunologic, Graft-Rejection, Immunity-Cellular, Immunity-Natural, Killer-Cells-Natural: im, Leukemia-Experimental: im, Mice, Mice-Inbred-Strains: im, Mice-Mutant-Strains: im, Neoplasm-Transplantation, SUPPORT-U-S-GOVT-P-H-S

JAX Location

5

JAX Source

Cell-Immunol. 1984 Sep; 87(2):348-56.

Grant

CA28231

Abstract

The effect of the beige (bg) mutation on adaptive allogeneic tumor rejection was examined by monitoring tumor cell survival in vivo using [131I]iododeoxyuridine-prelabeled cells. Accelerated elimination of allogeneic tumor cells normally begins 8 days after ip injection and is due to active immune responses. Two independent mutations to beige on two different inbred backgrounds (C57BL/6J bgJ and DBA/2JCo bg8J) were tested, and bg/bg mice showed a 1-day delay in immune elimination of allogeneic cells. This delayed rejection was not due to a defect in clearing label from dead cells, nor to an inability to effect antibody-induced killing in vivo. Both humoral and cell-mediated responses against the allogeneic tumor cells were significantly lower in bg/bg than in +/bg mice.

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