Faculty Research 1980 - 1989

Title

Inherited hemolytic disease in mice: a review and update.

Authors

S E. Bernstein

Document Type

Article

Publication Date

1980

Keywords

Animal, Blood-Proteins: an, Cell-Survival, Crosses-Genetic, Erythrocyte-Membrane: an, Erythrocytes: pa, Female, Genes, Hemoglobins: an, Hemolysis, Male, Membrane-Proteins: an, Mice, Mutation, Review, Spherocytosis-Hereditary: bl, fg, Splenomegaly: et, SUPPORT-U-S-GOVT-NON-P-H-S, SUPPORT-U-S-GOVT-P-H-S

JAX Location

43,789

JAX Source

Lab-Anim-Sci. 1980 Apr; 30():197-205.

Grant

HD00254, CA01074, AM25305

Abstract

There are four overt hemolytic diseases in the mouse which have almost identical clinical syndromes but are genetically distinct. These include hemolytic anemia (gene symble ha), jaundice (ja), normoblastic anemia (nb) and spherocytosis (sph). Each of the hemolytic disorders arises from an intrinsic defect in erythrocyte membrane proteins. Each of the responsible genes is involved, in some fashion, in the common process of membrane development and the maintenance of its integrity. Because each gene has its own special function, the gross phenotypic manifestations, although similar, must have a different functional basis.

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