Faculty Research 1980 - 1989

Title

Chromosomal location of a major tRNA gene cluster of Xenopus laevis.

Document Type

Article

Publication Date

1984

Keywords

Chromosome-Mapping, DNA-Ribosomal: ge, Female, Nucleic-Acid-Hybridization, Oocytes: an, Organ-Specificity, Repetitive-Sequences-Nucleic-Acid, RNA-Transfer: ge, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, Xenopus-laevis: ge

JAX Source

Chromosoma 1984;90(4):254-60

Grant

GM23241

Abstract

In Xenopus laevis, genes encoding tRNAPhe, tRNATyr, tRNAMet1, tRNAAsn, tRNAAla, tRNALeu, and tRNALys are clustered within a 3.18-kb (kilobase) fragment of DNA. This fragment is tandemly repeated some 150 times in the haploid genome and its components are found outside the repeat only to a limited extent. The fragment hybridizes in situ to a single site very near the telomere on the long arm of one of the acrocentric chromosomes of the group comprising chromosomes 13-18. All the chromosomes of this group also hybridize with DNA coding for oocyte-specific 5S RNA. The tRNA gene cluster is slightly proximal to the cluster of 5S RNA genes.

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