Faculty Research 1980 - 1989
Effects of cis-platinum on embryonal carcinoma cell lines in vitro.
Document Type
Article
Publication Date
1984
Keywords
Antigens-Neoplasm: an, Antigens-Surface: an, Cell-Differentiation: de, Cell-Line, Cells-Cultured, Cisplatin, Human, Mice, Stem-Cells: de, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, Teratoma: dt, im, pa, Tumor-Stem-Cells: de, pa
First Page
133
Last Page
139
JAX Source
Int J Cancer 1984 Jul 15;34(1):133-9
Grant
CA18470, CA23097, CA38405
Abstract
Human and mouse embryonal carcinoma (EC) cells lines were compared with several cell lines of a more differentiated phenotype for their relative sensitivities to the cytotoxic effects of cis-platinum (cis-diamine-dichloroplatinum; CDDP); EC lines were among the most sensitive. Furthermore, several markers of EC cell differentiation were not induced by CDDP, irrespective of the concentration of the drug used. These data provide an explanation for the relative sensitivity of the EC cells in non-seminomatous germ-cell tumors to cis-platinum therapy.
Recommended Citation
Oosterhuis JW,
Andrews PW,
Knowles BB,
Damjanov I.
Effects of cis-platinum on embryonal carcinoma cell lines in vitro. Int J Cancer 1984 Jul 15;34(1):133-9