Faculty Research 1980 - 1989

Title

Effects of cis-platinum on embryonal carcinoma cell lines in vitro.

Document Type

Article

Publication Date

1984

Keywords

Antigens-Neoplasm: an, Antigens-Surface: an, Cell-Differentiation: de, Cell-Line, Cells-Cultured, Cisplatin, Human, Mice, Stem-Cells: de, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, Teratoma: dt, im, pa, Tumor-Stem-Cells: de, pa

JAX Source

Int J Cancer 1984 Jul 15;34(1):133-9

Grant

CA18470, CA23097, CA38405

Abstract

Human and mouse embryonal carcinoma (EC) cells lines were compared with several cell lines of a more differentiated phenotype for their relative sensitivities to the cytotoxic effects of cis-platinum (cis-diamine-dichloroplatinum; CDDP); EC lines were among the most sensitive. Furthermore, several markers of EC cell differentiation were not induced by CDDP, irrespective of the concentration of the drug used. These data provide an explanation for the relative sensitivity of the EC cells in non-seminomatous germ-cell tumors to cis-platinum therapy.

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