Faculty Research 1980 - 1989

Title

Tumor radioimmunolocation: differential antibody retention by antigenic normal tissue and tumor.

Document Type

Article

Publication Date

1984

Keywords

Antibodies-Monoclonal: im, Antibody-Affinity, Antigens-Neoplasm: an, im, Antigens-Surface: an, im, Brain: im, Glycolipids: an, im, Kidney: im, Liver: im, Mice, Salivary-Glands: im, SUPPORT-U-S-GOVT-NON-P-H-S, SUPPORT-U-S-GOVT-P-H-S, Teratoma: im

JAX Source

J Immunol 1984 Apr;132(4):2111-6

Grant

CA31784, HD12487

Abstract

On the assumption that a high specificity would be required for in vivo tumor location and drug targeting, much labor has been expended to produce monoclonal antibodies directed to antigens found primarily on tumors. However, for at least one tumor-associated antigen, stage-specific embryonic antigen 1 (SSEA-1), the concentration of the target antigen need not be higher in the tumor than that found in normal tissues for successful use of the corresponding monoclonal antibody in in vivo tumor location; rather, accessibility and antibody metabolism are more important.

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