Faculty Research 1980 - 1989

Genes on different chromosomes influence the antibody response to bacterial antigens.

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Antibodies-Bacterial: bi, Antigenic-Determinants, Antigens-Bacterial: im, Chromosome-Mapping, Dextrans: im, Genes-Immune-Response, Mice, Mice-Inbred-Strains: im, Polysaccharides-Bacterial: im, Streptococcus-pneumoniae: im, SUPPORT-U-S-GOVT-P-H-S

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Immunogenetics. 1985; 22(3):269-76.




B6.C congenic strains of mice, possessing histocompatibility (H) alleles from high responding BALB/cBy (C) mice on the genetic background of low responding C57BL/6By (B6) mice, were assayed for their ability to make an antibody response to Type III pneumococcal polysaccharide (SSS-III) and the alpha(1----3) epitope of bacterial (Leuconostoc) dextran B-1355. The results affirmed that the antibody response to SSS-III is multigenic and that genes making a positive contribution to responsiveness are located on different chromosomes, i.e., chromosomes 1, 3, 4, 5, and 9. At least one other gene also influences responsiveness to SSS-III; it is linked to the H-17 locus, which has not yet been assigned to a specific chromosome. Genes on chromosomes 1, 4, and 5 influence the magnitude of the antibody response to dextran B-1355. Some of these genes may be antigen-specific in their mode of action; however, others may not since they appear to exert a positive influence on the antibody response to both SSS-III and dextran B-1355.

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