Faculty Research 1980 - 1989

Title

Chromosomal assignment of two endogenous ecotropic murine leukemia virus proviruses of the AKR/J mouse strain.

Document Type

Article

Publication Date

1985

Keywords

AKR-Virus: ge, Chromosome-Mapping, Defective-Viruses: ge, DNA-Viral: ge, Genes-Structural, Genes-Viral, Linkage-(Genetics), Mice, Mice-Inbred-AKR: ge, mi, Mice-Neurologic-Mutants: ge, Mouse-Leukemia-Viruses: ge, Salivary-Proteins: ge, Skin-Pigmentation, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

First Page

172

Last Page

175

JAX Source

J-Virol. 1985 Oct; 56(1):172-5.

Grant

CA33093, CA38039, CA37282, +

Abstract

The AKR/J mouse strain is genetically fixed for three different ecotropic murine leukemia virus genomes, designated Akv-1, Akv-3, and Akv-4 (Emv-11, Emv-13, and Emv-14). With recombinant inbred strains and crosses with linkage-testing stocks, Akv-3 and Akv-4 were placed on the mouse chromosome map. Akv-3, which encodes a replication-defective provirus, maps near the agouti coat color locus, a, on chromosome 2. Akv-4, which is replication competent, maps near the neurological mutant gene locus trembler, Tr, on chromosome 11. Akv-1 and Akv-2 (Emv-12), an ecotropic provirus carried by AKR/N but not AKR/J, have previously been mapped to chromosome 7 and 16, respectively. Thus, the four Akv proviruses mapped to date are on four different chromosomes. Akv-3 is the second ecotropic murine leukemia virus provirus to be mapped near the agouti locus. The results are discussed in relation to possible nonrandomness of viral integration.

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