Faculty Research 1980 - 1989

Title

Chromosomal assignment of two endogenous ecotropic murine leukemia virus proviruses of the AKR/J mouse strain.

Document Type

Article

Publication Date

1985

Keywords

AKR-Virus: ge, Chromosome-Mapping, Defective-Viruses: ge, DNA-Viral: ge, Genes-Structural, Genes-Viral, Linkage-(Genetics), Mice, Mice-Inbred-AKR: ge, mi, Mice-Neurologic-Mutants: ge, Mouse-Leukemia-Viruses: ge, Salivary-Proteins: ge, Skin-Pigmentation, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

JAX Source

J-Virol. 1985 Oct; 56(1):172-5.

Grant

CA33093, CA38039, CA37282, +

Abstract

The AKR/J mouse strain is genetically fixed for three different ecotropic murine leukemia virus genomes, designated Akv-1, Akv-3, and Akv-4 (Emv-11, Emv-13, and Emv-14). With recombinant inbred strains and crosses with linkage-testing stocks, Akv-3 and Akv-4 were placed on the mouse chromosome map. Akv-3, which encodes a replication-defective provirus, maps near the agouti coat color locus, a, on chromosome 2. Akv-4, which is replication competent, maps near the neurological mutant gene locus trembler, Tr, on chromosome 11. Akv-1 and Akv-2 (Emv-12), an ecotropic provirus carried by AKR/N but not AKR/J, have previously been mapped to chromosome 7 and 16, respectively. Thus, the four Akv proviruses mapped to date are on four different chromosomes. Akv-3 is the second ecotropic murine leukemia virus provirus to be mapped near the agouti locus. The results are discussed in relation to possible nonrandomness of viral integration.

Please contact the Joan Staats Library for information regarding this document.

Share

COinS