Faculty Research 1980 - 1989

Title

Variation in susceptibility to atherosclerosis among inbred strains of mice.

Document Type

Article

Publication Date

1985

Keywords

Aorta: pa, Arteriosclerosis: et, Atherosclerosis: et, ge, pa, Cholesterol, Comparative-Study, Diet-Atherogenic, Female, Mice, Mice-Inbred-Strains, Rats, Species-Specificity, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, Triglycerides

JAX Source

Atherosclerosis 1985 Oct; 57(1):65-73.

Grant

HL28943, BRSGRR05467

Abstract

Ten inbred strains of mice were fed an atherogenic diet containing 1.25% cholesterol, 0.5% cholic acid and 15% fat. The strains were examined for plasma cholesterol and triglyceride levels and for formation of lipid-containing lesions in the aortic wall. The strains differed considerably in the frequency of lesion formation after 14 weeks on the atherogenic diet with a range of 0-1.8 lesions/mouse. The order of susceptibility to lesion formation from the least susceptible to the most susceptible was BALB/cJ, C3H/J, A/J, SWR/J, NZB/J, less than 129/J, AKR/J, DBA/2J, less than C57L/J less than C57BL/6J. Total plasma cholesterol after 5 weeks on the diet varied from 131 mg/dl to 328 mg/dl among strains; however, there was little correlation between total cholesterol levels and susceptibility to lesion formation (r = 0.29). Plasma triglycerides after 5 weeks on the diet varied less than cholesterol with a range of 137-220 mg/dl. An analysis of the genetic differences among inbred strains of mice might provide useful insights into lipid metabolism and the development of atherosclerosis.

Please contact the Joan Staats Library for information regarding this document.

Share

COinS