Faculty Research 1980 - 1989

Title

Chromosomal site of hepatitis B virus (HBV) integration in a human hepatocellular carcinoma-derived cell line.

Document Type

Article

Publication Date

1985

Keywords

Cell-Line, Chromosomes-Human-6-12, Hepatitis-B-Surface-Antigens: ge, Hepatitis-B-Virus: ge, Hepatoma: ge, mi, Human, Hybrid-Cells: cy, Karyotyping, Liver-Neoplasms: ge, mi, Liver-Neoplasms-Experimental: ge, Rats, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Cytogenet Cell Genet 1985;39(2):116-20

Grant

CA18460, CA37225, CA10815

Abstract

The single site of integration of hepatitis B virus in the human hepatocellular carcinoma cell line Hep 3B 2-1/7 was found to segregate with human chromosome 12 in somatic cell hybrids. Analysis of metaphase spreads of Hep 3B 2-1/7 following in situ hybridization with pHBV revealed integration at 12q13----q14, a location that coincides with a fragile site, fra (12q13). The possible significance of this location to the development of hepatocellular carcinomas is discussed.

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