Faculty Research 1980 - 1989

Title

Autosomal aneuploidy in mice: generation and developmental consequences.

Document Type

Article

Publication Date

1986

Keywords

Animal, Chimera, Disease-Models-Animal, Mice, Mice-Neurologic-Mutants: ge, Phenotype, Review, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, Translocation-(Genetics), Trisomy

JAX Location

1,338.

JAX Source

Brain-Res-Bull. 1986 Jun; 16(6):789-801.

Grant

HD16303, HD17784

Abstract

Spontaneous aneuploidy in the mouse is uncommon, but specific mating schemes have been developed that produce aneuploid conceptuses at high frequencies. The most commonly reported aneuploid condition in the mouse is autosomal trisomy, in which there is an extra copy (in whole or in part) of a chromosome. In this review, we present several of the schemes used in producing trisomic, partially (tertiary) trisomic, and monosomic conceptuses and summarize the developmental consequences that are associated with each of the autosomal trisomies of the mouse.

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