Faculty Research 1980 - 1989

Title

The immunological network at the site of tumor rejection [published erratum appears in Biochim Biophys Acta 1986 Oct 28;865(2):233]

Authors

R Evans

Document Type

Article

Publication Date

1986

Keywords

Antigens-Neoplasm: im, Cyclophosphamide: tu, Human, Immune-Tolerance: de, Immunity-Cellular, Immunization-Passive, Immunotherapy, Macrophages: im, Neoplasms: im, th, Review, Sarcoma-Experimental: im, th, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, Suppressor-Cells: im, T-Lymphocytes: im, tr, Time-Factors

JAX Location

1324

JAX Source

Biochim-Biophys-Acta. 1986 Aug 5; 865(1):1-11.

Grant

CA27523

Abstract

The tumor mass irrespective of its type or location in the body has long been shrouded in mystery and even today we still have only a tentative handle on its secrets. Attempts to manipulate either the tumor cells per se or host-derived leukocytes have, on the whole, not been successful or at best questionable. The ability of the host to respond immunologically to TSTA is well documented, yet again attempts to manipulate this response have been disappointing. One of the problems has been a lack of knowledge concerning the tumor mass and its constituents, such as the intratumor leukocytes, and the significance of their presence to the biological properties of the neoplasm [8,9,80]. The purpose in studying the immunological network is, in part, to try to assign a function to these cells on the premise that lymphoid elements and macrophages have a potential role to play in recognition of TSTA. The advantage of adoptive immunotherapy model systems is that tumor rejection can be achieved under controlled conditions and this allows an analysis of the immunological network and its individual circuits. At the same time, valuable information on the mechanisms of action during adoptive immunotherapy and how best to improve therapeutic protocols is acquired.

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