Faculty Research 1980 - 1989

Title

The murine gamma-chain of the T cell receptor is closely linked to a spermatocyte specific histone gene and the beige coat color locus on chromosome 13.

Document Type

Article

Publication Date

1986

Keywords

Chromosome-Mapping, DNA-Restriction-Enzymes, Genotype, Histones: ge, Linkage-(Genetics), Male, Mice, Mice-Inbred-Strains, Mice-Mutant-Strains, Polymorphism-(Genetics), Receptors-Antigen-T-Cell: ge, Recombination-Genetic, Spermatocytes: me, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

JAX Source

J-Immunol. 1986 Aug 1; 137(3):1044-6.

Grant

AI18436, GM18684, AI19148, +

Abstract

With the use of standard genetic techniques, we have mapped the T cell gamma-chain gene locus (Tcrg) to the proximal end of mouse chromosome 13. Close genetic linkage was demonstrated between a restriction fragment length polymorphism in the Tcrg locus and a locus (HlS) encoding a spermatocyte-specific histone electrophoretic variant (HlS) by using recombinant inbred strains. Because HlS is closely linked to the dominant visible marker extra toes (Xt), Tcrg must be within 5 cM of the beige (bg) locus. Mice homozygous for the recessive mutation beige (bg/bg) show diminished pigmentation, enlarged lysosomes in granulocytes, and a selective deficiency of natural killer cell function. The bg mutation in mice is an animal model for humans with Chediak-Higashi syndrome; we speculate that the human gamma-chain may be closely linked to the human mutation and may be a useful diagnostic tool. Seven restriction enzymes identify five haplotypes of the highly polymorphic gamma-chain in mice.

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