Faculty Research 1980 - 1989

Title

Receptor-associated resistance to growth hormone-releasing factor in dwarf "little: mice.

Document Type

Article

Publication Date

1986

Keywords

Animal, Dwarfism-Pituitary: pp, pa, Female, Forskolin, Human, Mice, Mice-Inbred-C57BL, Mice-Mutant-Strains: ph, Pituitary-Gland-Anterior: de, an, pp, pa, Receptors-Endogenous-Substances: ph, me, Somatotropin-Releasing-Hormone: ph, me, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Science. 1986 Apr 25; 232(4749):511-2.

Grant

AM30667, AM17947

Abstract

Anterior pituitaries from the dwarf mouse strain "little: did not release growth hormone or accumulate adenosine 3',5'-monophosphate (cyclic AMP) in response to human and rat growth hormone-releasing factor (GRF). Dibutyryl cyclic AMP, as well as the adenylate cyclase stimulators forskolin and cholera toxin, markedly stimulated growth hormone (GH) release. The basis of the GH deficiency in the little mouse may therefore be a defect in an early stage of GRF-stimulated GH release related either to receptor binding or to the function of the hormone-receptor complex.