Faculty Research 1980 - 1989

Title

Mouse chromosome fragility.

Document Type

Article

Publication Date

1986

Keywords

Cells-Cultured, Chromosome-Banding, Chromosome-Fragile-Sites, Comparative-Study, Fluorodeoxyuridine, Genetic-Marker, Mice, Mice-Inbred-Strains: ge, Species-Specificity, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-NON-P-H-S, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Am-J-Med-Genet. 1986 Jan-Feb; 23(1-2):491-509.

Grant

HD17784, GM19656

Abstract

When cultures of fibroblast-like cells from inbred mouse strains RBC/Dn and AEJ/GnRk were exposed to 5-fluorodeoxyuridine (FUdR), non-random strain-specific distributions of chromosome gaps, breaks and exchanges were observed. Throughout the genomes there appeared to be specific sites at which lesions occurred preferentially. Two strain-specific fragile sites were identified in strain RBC/Dn at G-band 15A2, and at G-band 19B in strain AEJ/GnRk. Constitutive fragile sites at G-bands 12A2 and 18A2 were identified in both strains. A strain-specific marker at G-band 9B was found in strain AEJ/GnRk. The fragile sites reported here provide an animal model for the study of chromosome fragility as well as polymorphic markers for linkage studies.

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