Faculty Research 1980 - 1989
Two loci affecting B cell responses to B cell maturation factors.
Document Type
Article
Publication Date
1986
Keywords
Animal, B-Lymphocytes: de, im, Castration, Cells-Cultured, Chromosome-Mapping, Female, Growth-Substances, Interferon-Type-II, Lymphokines, Male, Mice, Mice-Inbred-C3H, Mice-Inbred-C57BL, Mice-Inbred-DBA, Mutation, Recombination-Genetic, SUPPORT-U-S-GOVT-P-H-S
First Page
116
Last Page
128
JAX Source
J-Exp-Med. 1986 Jan 1; 163(1):116-28.
Grant
CA35845, AI20232, AM17947, +
Abstract
B lymphocytes from DBA/2Ha mice have a genetic defect characterized by a failure to differentiate into antibody-secreting cells in response to a family of lymphokines termed B cell maturation factors (BMFs). By contrast, B cells from DBA/2Ha mice respond normally in PFC assays to the B cell mitogen LPS, and macrophages from these mice are activated by one of the three BMFs. Two loci are responsible for the B cell defect in DBA/2Ha mice. One locus (Bmfr-1) is constitutively expressed throughout life, and maps approximately 13 cM distal to the brown locus on chromosome 4. A second locus (Bmfr-2) becomes active only after sexual maturity and is closely linked to the dilute locus on chromosome 9. At both loci, alleles determining responsiveness to BMFs are dominant over nonresponder alleles. The effect of Bmfr-2 on B cell responsiveness may be related to levels of the steroid sex hormones. DBA/2Ha mice offer a tool for studying the genetic and hormonal regulation of the immune system.
Recommended Citation
Sidman CL,
Marshall JD,
Beamer WG,
Nadeau JH,
Unanue ER.
Two loci affecting B cell responses to B cell maturation factors. J-Exp-Med. 1986 Jan 1; 163(1):116-28.