Faculty Research 1980 - 1989

Title

Androgen induction of messenger RNA concentrations in mouse kidney is posttranscriptional.

Document Type

Article

Publication Date

1986

Keywords

Female, Kidney: de, me, Kinetics, Mice, Mice-Inbred-A, Mice-Inbred-DBA, RNA-Processing-Post-Transcriptional: de, RNA-Messenger: bi, ge, SUPPORT-U-S-GOVT-P-H-S, Testosterone, Transcription-Genetic: de

JAX Source

Biochemistry 1986; 25(5):1170-5.

Grant

AM31818, ES01170

Abstract

The concentrations of several mRNAs in mouse kidney increase in response to testosterone. To determine if the increases are generated at the level of gene transcription, we have assayed transcription rates for several androgen-inducible mRNAs in kidney nuclei in vitro. No significant changes were found in the synthesis of three mRNAs whose concentrations increase 10-20-fold during testosterone treatment. Kinetic analysis of changes in transcript levels after testosterone administration and withdrawal suggests that mRNA stabilization is a major factor in the inductions. Thus, the androgen-mediated induction of these kidney mRNAs is generated predominantly at the posttranscriptional level.

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