Faculty Research 1980 - 1989

Title

Red cell antigens P (globoside) and Luke: identification by monoclonal antibodies defining the murine stage-specific embryonic antigens -3 and -4 (SSEA-3 and SSEA-4).

Document Type

Article

Publication Date

1986

Keywords

Antibodies-Monoclonal: im, Antigens: im, Blood-Groups: im, Gene-Frequency, Globosides: im, Glycolipids: im, Human, Mice, P-Blood-Group-System: ge, im, Phenotype, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Vox Sang 1986;51(1):53-6

Grant

CA29894, HD12487, CA18470

Abstract

Two globoseries antigens (antigens borne on carbohydrate chains containing globoside), SSEA-3 and SSEA-4, were found on the red cells of the majority of people, but were absent from cells of rare p and Pk individuals which lack globoside. In addition, SSEA-4 was absent from red cells of Luke(-) individuals which nevertheless express the P antigen (globoside) and SSEA-3. The name LKE is proposed for the red cell antigen detected by the Luke serum and by MC813-70, the monoclonal antibody defining SSEA-4. Among the LKE+ individuals, a few showed relatively weak expression of the antigen and were grouped separately as a LKE weak (LKEw) phenotype. Using MC813-70, the frequencies of the 3 phenotypes LKE+, LKEw and LKE- in an English donor population are 0.914, 0.072 and 0.014, respectively.

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