Faculty Research 1980 - 1989

Title

Tumor location and drug targeting using a monoclonal antibody (anti-SSEA-1) and antigen-binding fragments.

Document Type

Article

Publication Date

1986

Keywords

Antibodies-Monoclonal: du, Antigens-Neoplasm: im, Antineoplastic-Agents, Choriocarcinoma: ri, Female, Glycolipids: im, Human, Immunoglobulins-Fab: im, Iodine-Radioisotopes: du, Mice, Mice-Inbred-BALB-C, Neoplasm-Transplantation, Neoplasms-Experimental: ri, Pregnancy, SUPPORT-U-S-GOVT-NON-P-H-S, SUPPORT-U-S-GOVT-P-H-S, Teratoma: ri, Transplantation-Heterologous

JAX Source

J Surg Oncol 1986 Jan;31(1):1-12

Grant

HD12487, 14551, 31784

Abstract

Both murine and heterotransplanted human nonseminomatous germ-cell tumors have been successfully located by external scintigraphy using radioiodinated anti-SSEA-1, a monoclonal IgM, and its pepsin-derived antigen-binding fragment, F(ab')2 mu. Antibody localization in the tumor is mainly due to antigenic specificity, rather than to nonspecific trapping, and depends strongly on the amount of time after injection. The antibody has been used for drug targeting in vitro and in vivo.

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