Faculty Research 1980 - 1989
Title
Characterization of somatically acquired ecotropic and mink cell focus-forming viruses in lymphomas of AKXD recombinant inbred mice.
Document Type
Article
Publication Date
1987
Keywords
Animal, Chromosome-Mapping, DNA-Viral, Lymphoma, Mice-Inbred-DBA, Mink-Cell-Focus-Inducing-Viruses Mouse-Leukemia-Viruses, Proto-Oncogenes, Recombination-Genetic
First Page
2929
Last Page
2933
JAX Source
J Virol. 1987 Sep; 61(9):2929-33.
Grant
CA37283, CA33093, N01-CO-23909
Abstract
The DNA of lymphomas from 12 AKXD recombinant inbred mouse strains was analyzed to determine the presence of somatically acquired ecotropic and mink cell focus-forming proviruses. Mink cell focus-forming proviruses were associated primarily with T-cell lymphomas, whereas ecotropic proviruses were associated with lymphomas of B-cell and myeloid lineages. A model based on the results is proposed to explain the variation in lymphoma types observed in different AKXD strains.
Recommended Citation
Mucenski ML,
Taylor BA,
Copeland NG,
Jenkins NA.
Characterization of somatically acquired ecotropic and mink cell focus-forming viruses in lymphomas of AKXD recombinant inbred mice. J Virol. 1987 Sep; 61(9):2929-33.