Faculty Research 1980 - 1989

Title

Characterization of somatically acquired ecotropic and mink cell focus-forming viruses in lymphomas of AKXD recombinant inbred mice.

Document Type

Article

Publication Date

1987

Keywords

Animal, Chromosome-Mapping, DNA-Viral, Lymphoma, Mice-Inbred-DBA, Mink-Cell-Focus-Inducing-Viruses Mouse-Leukemia-Viruses, Proto-Oncogenes, Recombination-Genetic

JAX Source

J Virol. 1987 Sep; 61(9):2929-33.

Grant

CA37283, CA33093, N01-CO-23909

Abstract

The DNA of lymphomas from 12 AKXD recombinant inbred mouse strains was analyzed to determine the presence of somatically acquired ecotropic and mink cell focus-forming proviruses. Mink cell focus-forming proviruses were associated primarily with T-cell lymphomas, whereas ecotropic proviruses were associated with lymphomas of B-cell and myeloid lineages. A model based on the results is proposed to explain the variation in lymphoma types observed in different AKXD strains.