Faculty Research 1980 - 1989
Title
Adenosine deaminase activity in recipients of bone marrow from immunodeficient mice homozygous for the wasted mutation.
Document Type
Article
Publication Date
1987
Keywords
Animal, Bone-Marrow: tr, Homozygote, Immunologic-Deficiency-Syndromes: en, Mice, Mice-Inbred-C57BL, Mice-Inbred-HRS, Mice-Mutant-Strains, Mutation, Nucleoside-Deaminases: me, SUPPORT-U-S-GOVT-P-H-S, Tissue-Distribution
JAX Source
Biochem-Biophys-Res-Commun. 1987 May 29; 145(1):581-5.
Grant
GM23200, CA35048
Abstract
Mice homozygous for the mutation wasted (wst/wst) have been postulated to be a model for the form of human severe combined immunodeficiency disease (SCID) that is secondary to a genetic deficiency of adenosine deaminase (ADA). To test this hypothesis more critically, we transplanted marrow from wst/wst and littermate control mice into lethally irradiated normal recipients. The Vmax and Km values for ADA in recipient's hematologic and non-hematologic tissues did not differ significantly. These results indicate that the wasted mouse is not a model for ADA deficiency and SCID.
Recommended Citation
Willis, E H.; Carson, D A.; and Shultz, L D., " Adenosine deaminase activity in recipients of bone marrow from immunodeficient mice homozygous for the wasted mutation." (1987). Faculty Research 1980 - 1989. 867.
https://mouseion.jax.org/stfb1980_1989/867