Faculty Research 1980 - 1989

Title

Adenosine deaminase activity in recipients of bone marrow from immunodeficient mice homozygous for the wasted mutation.

Document Type

Article

Publication Date

1987

Keywords

Animal, Bone-Marrow: tr, Homozygote, Immunologic-Deficiency-Syndromes: en, Mice, Mice-Inbred-C57BL, Mice-Inbred-HRS, Mice-Mutant-Strains, Mutation, Nucleoside-Deaminases: me, SUPPORT-U-S-GOVT-P-H-S, Tissue-Distribution

JAX Source

Biochem-Biophys-Res-Commun. 1987 May 29; 145(1):581-5.

Grant

GM23200, CA35048

Abstract

Mice homozygous for the mutation wasted (wst/wst) have been postulated to be a model for the form of human severe combined immunodeficiency disease (SCID) that is secondary to a genetic deficiency of adenosine deaminase (ADA). To test this hypothesis more critically, we transplanted marrow from wst/wst and littermate control mice into lethally irradiated normal recipients. The Vmax and Km values for ADA in recipient's hematologic and non-hematologic tissues did not differ significantly. These results indicate that the wasted mouse is not a model for ADA deficiency and SCID.

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