Adenosine deaminase activity in recipients of bone marrow from immunodeficient mice homozygous for the wasted mutation.

Authors

E H. Willis
D A. Carson
L D. ShultzFollow

Document Type

Article

Publication Date

1987

Keywords

Animal, Bone-Marrow: tr, Homozygote, Immunologic-Deficiency-Syndromes: en, Mice, Mice-Inbred-C57BL, Mice-Inbred-HRS, Mice-Mutant-Strains, Mutation, Nucleoside-Deaminases: me, SUPPORT-U-S-GOVT-P-H-S, Tissue-Distribution

First Page

581

Last Page

585

JAX Source

Biochem-Biophys-Res-Commun. 1987 May 29; 145(1):581-5.

Grant

GM23200, CA35048

Abstract

Mice homozygous for the mutation wasted (wst/wst) have been postulated to be a model for the form of human severe combined immunodeficiency disease (SCID) that is secondary to a genetic deficiency of adenosine deaminase (ADA). To test this hypothesis more critically, we transplanted marrow from wst/wst and littermate control mice into lethally irradiated normal recipients. The Vmax and Km values for ADA in recipient's hematologic and non-hematologic tissues did not differ significantly. These results indicate that the wasted mouse is not a model for ADA deficiency and SCID.

Recommended Citation

Willis EH, Carson DA, Shultz LD. Adenosine deaminase activity in recipients of bone marrow from immunodeficient mice homozygous for the wasted mutation. Biochem-Biophys-Res-Commun. 1987 May 29; 145(1):581-5.