Faculty Research 1980 - 1989
Title
Adenosine deaminase activity in recipients of bone marrow from immunodeficient mice homozygous for the wasted mutation.
Document Type
Article
Publication Date
1987
Keywords
Animal, Bone-Marrow: tr, Homozygote, Immunologic-Deficiency-Syndromes: en, Mice, Mice-Inbred-C57BL, Mice-Inbred-HRS, Mice-Mutant-Strains, Mutation, Nucleoside-Deaminases: me, SUPPORT-U-S-GOVT-P-H-S, Tissue-Distribution
First Page
581
Last Page
585
JAX Source
Biochem-Biophys-Res-Commun. 1987 May 29; 145(1):581-5.
Grant
GM23200, CA35048
Abstract
Mice homozygous for the mutation wasted (wst/wst) have been postulated to be a model for the form of human severe combined immunodeficiency disease (SCID) that is secondary to a genetic deficiency of adenosine deaminase (ADA). To test this hypothesis more critically, we transplanted marrow from wst/wst and littermate control mice into lethally irradiated normal recipients. The Vmax and Km values for ADA in recipient's hematologic and non-hematologic tissues did not differ significantly. These results indicate that the wasted mouse is not a model for ADA deficiency and SCID.
Recommended Citation
Willis EH,
Carson DA,
Shultz LD.
Adenosine deaminase activity in recipients of bone marrow from immunodeficient mice homozygous for the wasted mutation. Biochem-Biophys-Res-Commun. 1987 May 29; 145(1):581-5.