Faculty Research 1980 - 1989

Chromosomal location of Evi-1, a common site of ecotropic viral integration in AKXD murine myeloid tumors.

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Chromosome-Mapping, Crosses-Genetic, Epidermal-Growth-Factor-Urogastrone: ge, Leukemia-Experimental: fg, me, mi, Leukemia-Myelocytic: fg, me, mi, Mice, Mice-Inbred-A, Mice-Inbred-AKR, Mice-Inbred-BALB-C, Mice-Inbred-C3H, Mice-Inbred-C57BL, Mice-Inbred-DBA, Proto-Oncogenes, Recombination-Genetic, Restriction-Fragment-Length-Polymorphisms, Retroviridae: me, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

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Oncogene Res 1988 Feb; 2(3):219-33.


CA37283, CA33093, NO1-CO-23909


The chromosomal location of Evi-1, a common site of ecotropic viral integration in AKXD murine myelogenous leukemias, was determined by recombinant inbred and conventional backcross analyses. We mapped Evi-1 to a location approximately 15 cM distal to the carbonic anhydrase locus on murine Chromosome 3. The chromosomal location of the proto-oncogene Nras, and two growth factors, epidermal growth factor (Egf), and the beta subunit of nerve growth factor (Ngfb), which had previously been assigned to Chromosome 3 by somatic cell hybrid analysis, were also determined. The location of Evi-1 is distinct from these three loci and from all other proto-oncogenes, common sites of viral integration, or growth factor loci previously mapped in mouse chromosomes. These results suggest that Evi-1 represents a new locus involved in myeloid disease.

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