Blockade of CD40-CD154 interferes with human T cell engraftment in scid mice.
Cell Transplant 1998 Jan-Feb;7(1):25-35
Antibodies to the ligand for CD40 (CD154) have been shown to exert profound effects on the development of cell-mediated immune responses in mice. The present study shows that an antibody to human CD154 (hCD40L) inhibits in vivo Tetanus toxoid (TT) specific secondary antibody responses in hu-PBL-scid mice, as well as the expansion of xenoreactive human T cells in the scid mice. A possible cause for the reduced expansion of xenoreactive, human T cells, was the decreased expression of murine B7.1 and B7.2 caused by the administration of anti-hCD40L. Therefore, it may be that defective maturation of murine antigen-presenting cells impeded the priming and expansion of human xenoreactive T cells.
Foy, T M.; McIlraith, M; Masters, S R.; Dunn, J J.; Rossini, A A.; Shultz, L D.; Hesselton, R A.; Wagar, E J.; Lipsky, P E.; Noelle, R J.; and Greiner, D L., " Blockade of CD40-CD154 interferes with human T cell engraftment in scid mice." (1998). Faculty Research 1990 - 1999. 1043.