The same genetic regions encode minor histocompatibility antigens detected in the context of different MHC haplotypes.

Authors

H Klinge
D C. RoopenianFollow

Document Type

Article

Publication Date

1999

Keywords

Antigens-Bacterial: an, ge, im, Chromosomes: ge, Epitopes: ge, Female, Graft-Rejection: im, Haplotypes: ge, Immunization, Major-Histocompatibility-Complex: ge, Mice, Mice-Inbred-Strains, Minor-Histocompatibility-Antigens: ge, Skin-Transplantation, Spleen: im, cy, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, T-Lymphocytes-Cytotoxic: im

First Page

1178

Last Page

1183

JAX Source

Transplantation 1999 Apr 27;67(8):1178-83

Grant

R01, R01, R01CA34196/CA/NCI

Abstract

The mammalian genome encodes numerous autosomal minor histocompatibilty (H) antigens that act as a barrier to allogeneic tissue transplantation when donor and recipient are matched for the major histocompatibilty complex (MHC). However, most of our understanding of the genetic basis of such minor H antigens is limited to analysis of mouse strains of the H2b haplotype. To broaden our understanding, we investigated minor H antigens detected in the context of other MHC alleles. As measured by graft survival and precursor cytotoxic T lymphocytes from blood, our results suggest that chromosomal segments known to encode minor H antigens detected in the context of the H2b haplotype are antigenically complex in that they also frequently encode minor H antigens that can be detected in the context of at least the H2d and H2k haplotypes. Genetic models to account for this complexity are discussed.

Recommended Citation

Klinge H, Roopenian DC. The same genetic regions encode minor histocompatibility antigens detected in the context of different MHC haplotypes. Transplantation 1999 Apr 27;67(8):1178-83