Rescue of cyclin D1 deficiency by knockin cyclin E.
Cyclin-D1: ge, df, me, Cyclin-E: ge, me, Human, Mice, Mice-Inbred-C57BL, Phenotype, Receptors-Estrogen: me, Retina: me, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S
Cell 1999 Jun 11;97(6):767-77
D-type cyclins and cyclin E represent two very distinct classes of mammalian G1 cyclins. We have generated a mouse strain in which the coding sequences of the cyclin D1 gene (Ccnd1) have been deleted and replaced by those of human cyclin E (CCNE). In the tissues and cells of these mice, the expression pattern of human cyclin E faithfully reproduces that normally associated with mouse cyclin D1. The replacement of cyclin D1 with cyclin E rescues all phenotypic manifestations of cyclin D1 deficiency and restores normal development in cyclin D1-dependent tissues. Thus, cyclin E can functionally replace cyclin D1. Our analyses suggest that cyclin E is the major downstream target of cyclin D1.
Geng, Y; Whoriskey, W; Park, M Y.; Bronson, R T.; Medema, R H.; Li, T; Weinberg, R A.; and Sicinski, P, " Rescue of cyclin D1 deficiency by knockin cyclin E." (1999). Faculty Research 1990 - 1999. 1267.