Expression of Delta1 and Serrate1 (Jagged1) in the mouse inner ear.
Animal, Cochlea, Gene-Expression-Regulation-Developmental, In-Situ-Hybridization, Labyrinth, Membrane-Proteins, Mice, Mice-Knockout, Proteins, SUPPORT-U-S-GOVT-NON-P-H-S
Mech Dev 1999 Jun; 84(1-2):169-72.
The Notch signalling pathway is thought to play a key part in controlling the production of sensory hair cells in the vertebrate inner ear via lateral inhibition; but there is disagreement as to which Notch ligands are expressed in hair cells as they develop. We show, using a mouse Delta1:LacZ knock-in as a reporter, that nascent hair cells, but not their neighbours, express Delta1. Expression of Serrate1 (Jagged1), meanwhile becomes restricted to the supporting cells of each sensory patch. Delta1 is also expressed: (a) at early stages, at the site of otic neurogenesis; and (b) in scattered cells of the endolymphatic sac, as is Serrate1.
Morrison, A; Hodgetts, C; Gossler, A; Hrabe, d e.; and Lewis, J, " Expression of Delta1 and Serrate1 (Jagged1) in the mouse inner ear." (1999). Faculty Research 1990 - 1999. 1300.